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NEMO
What is NEMO?
NEMO is the name of a gene that regulates functions of the immune system.
NEMO is like a "master switch" that is found on the cell of the human body and regulates signals between the cell membrane and the cell nucleus. NEMO is expressed in almost all tissue cells. If NEMO is not present life is not possible. NEMO stands for Nuclear Factor Kappa B Essential Modulator.
Nuclear Factor Kappa B or NFKB is the name of the protein that is used for communication between the membrane and the nucleus. NEMO is known to be the pathway of skin, skeleton, blood vessel and other vital signals. For example, the EDA gene is known to dictate properties of the "ectoderm" or last layer of the skin. The EDA gene uses the NEMO pathway to the nucleus to make the "ectoderm" properties present.
Articles about NEMO by Dr. Jordan Orange

The presentation and natural history of immunodeficiency caused
by nuclear factor kappaB essential modulator mutation.
Jordan S. Orange, et al. (
web site - article)

Finding Nemo: genetic disorders of NFkB activation.
Jordan S. Orange (
web site - article) &
 Raif S. Geha (
web site - article)

Deficient natural killer cells cytoxicity in patients with
IKK-y/NEMO mutations.
Jordan S. Orange, et al. (
web site - article)

 

 

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